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Adverse events leading to dose reduction: 18.5% vs 12.4% Adverse events leading to permanent discontinuation: 5.4% vs 4.0% As a reminder, these are people who signed up to be in a trial of weight loss medications, they went through an informed consent process and they are, in theory, quite motivated and 4-5% permanently discontinued the medication because of adverse events and 12-18.5% reduced their dose and thats just in 72 weeks

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That means the real answer is not a simple yes or no